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Holding the Alt key enables different operations. By default, Alt allows you to return to the slice where scrolling began.
    Usage:
  • Hold Alt and scroll through slices
  • Release Alt to return to the original slice
Alternatively, you can hold Alt and use the scroll wheel to change time points in 5D datasets.

You can select between these modes in
Menu → File → Preferences → User Interface → Hold Alt with Scroll Wheel